Iyad Nassib Karame

Full professor
Chemistry - Biochemistry department - Section I - Hadath
Speciality: Chemistry
Specific Speciality: كيمياء فيزيائية

Teaching 4 Taught Courses
2000 - 2003: PhD

Claude Bernard Lyon1 UNiversity
Asymmetric Catalysis, Organometallic and Organic Chemistry

1999 - 2000: DEA

Claude Bernard Lyon1 UNiversity
Catalyse et Chimie Physique des Interfaces

1993 - 1997: Maitrise

Lebanese UNiversity, Faculty of SCiences 1

1990 - 1993: BaccII

Aîn-zhalta Official High School
SEcondary Studies

1984 - 1989: Brevet

AÏn-zhalta Official School

1978 - 1983:

Sacré Coeur, Ain-Zhalta
Elementary Studies

Publications 27 publications
Bilal El-Asaad, Estelle Métay, Iyad Karamé, Marc Lemaire Chiral N-arylated diamine–Copper complexes catalyzed asymmetric Henry reaction Molecular Catalysis, Elesevier 2017

Asymmetric Henry reaction between benzaldehyde derivatives and nitomethane leading to 2-nitro-1-aryl-ethanol has been developed. It was found that N,N’-diarylated diamine ligands and N-aryl diamine induce enantioselectivity when(or when they are) combined to copper (II). The presence of triethylamine is crucial in case of N,N’-binaphthalene diamine at only low temperature (−20 °C), however in case of N-naphthalene diamine ligand there is no need of adding an external base. Good enantioselectivities (up to 83%) with good isolated yield were obtained using a catalytic loading of 10% mol at room temperature

M Wehbie, G Arrachart, C Arrambide Cruz, I Karamé, L Ghannam, S Pellet-Rostaing Organization of diglycolamides on resorcinarene cavitand and its effect on the selective extraction and separation of HREEs Separation and Purification Technology, Elesevier 2017

Two calix(4)resorcinarene based cavitands, one that contains four triazole units, calix(4)resorcinarene-tetra(hexyltriazole) CR4-Tz LI, and another that contains four triazole diglycolamide units, calix(4)resorcinarene-tetra(didecyldiglycolamidetriazole) CR4-Tz-DDDGA LII, were synthesized and fully characterized by IR, NMR, and MS. The efficiency of the two cavitands were compared toward the extraction of 7 lanthanides (Ce(III), Nd(III), Sm(III), Gd(III), Dy(III), Er(III), Yb(III)) in chloroform from 5 M HNO3. The extraction study showed that LI, which contains only the triazole units, is unable to extract any of the targeted metals. The effects of the organization and diluents on the distribution coefficients and the selectivity of LII were also studied toward the same lanthanide series at the same acidity. The obtained results showed that the cavitand is selective toward heavy lanthanides irrespective of the diluents. The extraction and stripping experiments of the 7 Ln(III) and the separation of Nd and Dy from a Fe-B-Nd-Dy leaching solution were performed

Samira Zaher, Lorraine Christ, Mohamad Abd El Rahim, Ali Kanj, Iyad Karamé Green acetalization of glycerol and carbonyl catalyzed by FeCl 3· 6H 2 O Molecular Catalysis, Elesevier 2017

A new and mild method of glycerol acetalization reaction with various carbonyl compounds catalyzed by the cheap and simple iron catalyst FeCl3·6H2O has been developed. This method which consists in the transformation of glycerol to cyclic acetals under mild conditions, with or without solvent, allowed interesting results: glycerol acetalization using ketones leads to the corresponding 1,3-dioxolanes with a very good selectivity (97–100%), whereas mixture of 1,3-dioxolanes and 1,3-dioxanes was formed when using aldehydes, with a good selectivity toward 1,3-dioxanes up to 76%

S Shehayeb, X Deschanels, I Karamé, L Ghannam, G Toquer Spectrally selective coatings obtained from electrophoretic deposition of CuO nanoparticles Surface and Coatings Technology, Elesevier 2017

Cathodic electrophoretic deposition (EPD) of CuO nanoparticles is investigated for the formation of CuO tandem photothermal absorber starting from CuO-isopropanol suspension. Prior to the deposition step, the stabilization of the suspension in request is achieved via the addition of Mg(NO3)2 acting as a stabilizer but, also as a binder for the final coating. The colloidal dispersion stability is studied as a function of the concentration of Mg(NO3)2 added to the suspension by dynamic light scattering coupled with laser doppler velocimetry in order to determine the size and the charge of particles respectively. EPD parameters, such as the electric field and deposition time, have been investigated in order to control the thickness and the morphology in order to select the most promising coatings. The evolution of the thickness, obtained from scanning electron microscopy images, as a function of deposition time for different applied electric field is in agreement with a linear Hamaker law type. This is also used here as a first attempt to extract the effective density of the coating. Finally, the conversion efficiency of the tandem material is calculated from the reflectance spectra of the UV–vis-NIR and the Fourier transform InfraRed spectroscopy in order to link the EPD parameters to the spectral selectivity. The optimal coating was formed with an applied electric field of 50 V·cm− 1 for a deposition time of 30 min yield the highest efficiency at 0.8

Iyad Karamé & Hassan SROUR Green Chemical Processing and Synthesis InTech 2017

Sustainable development and alternative energy constituted urgent needs in the last decade. Renewable chemicals, energy and bio-resource use became challenging topics in the sustainable, renewable and green sciences. This encourages and turns primordial needs the works in certain fields as developing of new and green catalysts for chemical transformations, in the domains of energy, environmental, pharmaceutical, agro-alimentary and cosmetically applications; evaluation of bio-resources compounds largely available for many applications in energy or as additives to fuels and other applications, reduction and conversion of greenhouse gas as well as developing new synthesis routes by avoiding the use of toxic and environmentally damage materials. In this book, the recent sustainable and green process is presented in three sections: "Greenhouse Gas Conversion Efficiency in Microwave", "Biomass Green Process" and "Green Synthesis and Catalysis"

Bilal El-Asaad, Boris Guicheret, Estelle Métaya , Iyad Karamé, Marc Lemaire Novel access to N, N′-diaryl-trans-1, 2-diaminocyclohexane ligands. A cheap and easy way to prepare ligand for asymmetric transfer hydrogenation Journal of Molecular Catalysis A: Chemical, Elesevier 2016

N, N′-diaryl-trans-1, 2-diaminocyclohexane ligands were prepared from 1, 2- diaminocyclohexane and cyclohexanone derivatives via a heterogeneous palladium catalysis. In one step an alkylation followed by an aromatisation is performed under air or in the presence of an hydrogen trap. The interest of the synthesized ligands were evaluated in the reduction of aromatic ketones. The alcohols were efficiently and selectively obtained with an iridium complex and a mixture of formic acid and sodium formate.

Wissam Zahreddine, Quentin Lelong, Iyad Karamé, Ali Kanj, Catherine Pinel, Laurent Djakovitch, Franck Rataboul Synthesis of terpene derivatives of ethanolamine using telomerization reaction Tetrahedron Letters, Pergamon 2016

This Letter describes novel families of terpene derivatives bearing amino and alcohol functions, synthetically obtained through the telomerization of ethanolamine with isoprene. This reaction was performed at 90 C in methanol and catalyzed by a Pd/PPh system. Four different product families were obtained depending on the telomerization degree with a total yield upto 85%. Monotelomers and ditelomers have been found to form preferentially. A variation of reagent stoichiometry allowed the tuning of the monotelomer and ditelomer selectivities within a 50–80% and 20–50% range, respectively. The best compromise total yield/monotelomer selectivity was obtained with 2 equiv of isoprene per ethanolamine. Deep analysis by NMR spectroscopy indicated that the monotelomer family was composed of 6 isomers, the main isomer possessing a tail-to-head trans configuration with a selectivity of 32.5% among all monotelomers.

M Wehbie, G Arrachart, I Karamé, L Ghannam, S Pellet-Rostaing Triazole Diglycolamide Cavitand for lanthanide extraction Separation and Purification Technology, Elesevier 2016

Click chemistry, which relies on the efficiency of the copper (I)-catalyzed azide-alkyne cycloaddition, was used to link four diglycolamide (DGA) moieties to a resorcinarene platform leading to a specific tetra-DGA-resorcinarene ligand (c-methylcalix(4)methylresorcinarene-4-triazole-dioctyldiglycolamide denoted CR4-Tz-DODGA). The extraction ability of this ligand was studied in a mixture of toluene/iso-octanol (90/10, v/v) toward rare earth elements (REE) at different nitric acid concentrations, ranging from 1 to 5 M. The results show the efficient extractability of and selectivity towards heavy REEs. The stoichiometry of the extraction was established by the slope analysis method and an extraction mechanism was proposed based on estimates of the thermodynamic parameters. From the extraction behavior of the tetra-DGA-resorcinarene ligand, we present the possibility for the extraction and separation of dysprosium from used permanent magnets.

Edited by Iyad Karamé, Co-Editor: Hassan Srour Recent Advances in Organocatalysis Intechopen 2016

Organocatalysis has recently attracted enormous attention as green and sustainable catalysis. It was realized as a fundamental field providing wide families of catalysts for important organic transformations. It will certainly develop in the future. Given the diversity of accessible transformations, metal-catalysed reactions have become major tools in organic synthesis that will undoubtedly continue to have an important impact in the future. Alternatively, over the last years, a metal-free approach like organocatalysis has reached a level of faithfulness allowing researchers to discover new catalytic systems based on engagement of new or early-prepared organic molecules as organocatalysts. Organocatalysis meet green chemistry principles, especially the reduction of toxicity and chemical accidents, the biodegradability, the use of benign and friendlier reaction media and conditions

Moheddine Wehbie, Guilhem Arrachart, Iyad Karamé, Leila Ghannamb and Stéphane Pellet-Rostaing Diglycolamide-Functionalized Resorcinarene for Rare Earths Extraction RSC 2016

A C-methylcalix(4)methylresorcinarene–DODGA ligand, derived from calix[4]methylresorcinarene functionalized with four diglycolamide (DGA) binding units, was synthesized and characterized by NMR and MS. The ligand was investigated with respect to the extraction of rare earth elements (REEs) from nitric acid solution. High sensitivity was observed, particularly toward heavy rare earth elements. The acidity effects, as well as the concentration of the extractant, were evaluated with regard to the extraction and separation efficiencies. The results showed that the distribution coefficient values increase with an increase in nitric acid concentration in the range from 0.1 to 5 mol L−1. A slope analysis method and spectrophotometric titrations showed clear complexation of the REEs with the ligand. An extraction mechanism is proposed from the estimation of the thermodynamic parameters (ΔH, ΔS, and ΔG). The extraction and stripping of REEs from a simulated leaching solution of a Nd/Fe/B/Dy magnet have been studied.

Chloe Thieuleux, Christophe Coperet, Laurent Veyre, Robert Corriu, Catherine Reye, Ahmad Mehdi, Jean-Marie Basset, Tarun Maishal, Malika Boualleg, Iyad Karame, Jean-Michel Camus, Johan Alauzun Hybrid organic-inorganic materials that contain stabilized carbene US Patent 8,871,877, 2014 2014

The present invention relates to materials and particularly “organometallic-organic-inorganic hybrid materials” that can be used as heterogeneous catalysts for selective catalytic reactions. More precisely this invention relates to organic-inorganic hybrid nanostructured materials comprising a regularly distributed stabilized carbene that binds strongly to a metal so as to form a stable organometallic-organic-inorganic hybrid material having high catalytic performances.

Mohamad Abd El Rahim, Leila Ghannam, Rodolfe Antoine, Philippe Dugourd, Driss Rayane, Michel Broyer, Iyad Karamé Structure and permanent electric dipole of para-fluoroaniline in gaseous phase Central European Journal of Chemistry 2013

By coupling a matrix assisted laser desorption source to an electric beam deflection setup, we have measured the permanent electric dipole moment of the isolated para-fluroaniline PFAN (FC6H4NH2) molecule in the ground state. This measurement of the electric dipole of an isolated push-pull molecule is unique. The experimental value is compared to two different calculations and the structure of the system is discussed.

Edited by Iyad Karamé Hydrogenation INTECH Open Access Publisher 2012

The domain of catalytic hydrogenation continues to grow fast, reflecting the wide range of chemical applications that can be enhanced by the easy use of molecular hydrogen. The advances in characterization techniques and their application have improved our understanding of the catalytic processes and mechanisms occurring in both homogeneous and heterogeneous catalysis. The aim of this volume, although not exhaustive, is to provide a general overview of new progress of the hydrogenation reactions. This volume comprises a series of various contributions, as reviews or original articles, treating heterogeneously and homogeneously catalyzed hydrogenation reactions. It is composed of three parts: hydrogenation reactions in fine organic chemistry, hydrogenation reactions in environmental chemistry and renewable energy, and special topics in hydrogenation.

Ismail Abbas, Jinane K Chaaban, Iyad Karamé Modified Saw Dust for the Removal of Lead Cations from Aqueous Media International Journal of Chemistry 2012

Saw dust modified with chloroethylacetate was prepared. The product was used as an extracting agent for the solid-phase extraction of lead cations from aqueous media. The uptake performance of modified saw dust (MSD) for removal of Pb(II) cations was investigated using batch method. The influences of some experimental parameters like initial concentration of the cation, extraction time, concentration of the saw dust, pH and temperature were studied. Three adsorption isotherms [Langmuir, Freundlich and Dubinin-Redushkevish (D-R)] were used to analyze the equilibrium data. The sorption capacity of modified saw dust was found to be 78.1 mg/g at 298 K from 164 mg/l aqueous solution of lead cation. The mean free energy calculated from D-R model was found to be 15.81 KJ/mol, indicating that chemisorption is involved in the extraction process. The removal of lead cation does not change with increasing temperature. The present method has been compared with the previous methods

Iyad Karamé, Ghinwa Nemra-Baydoun, Radwan Abdallah, Ali Kanj, Armin Börner Highly Regioselective Synthesis of Ethyl 2-(N-Methylformate-1, 4, 5, 6-tetrahydropyridin-2-yl) Acetate and Its Conversion into Corresponding (R)-Ethyl Homopepicolate by Asymmetric Hydrogenation Synthetic communications, Taylor & Francis Group 2011

Ethyl 2-(N-methylformate-1,4,5,6-tetrahydropyridin-2-yl) acetate with endocyclic double bond was prepared with high regioselectivity and further reduced into (R)-N-protected homopipecolate with a good enantioselectivity using chiral ruthenium catalys

Iyad Karamé, Mohamad Alamé, Ali Kanj, Ghinwa Nemra Baydoun, Hassan Hazimeh, Mirvat el Masri, Lorraine Christ Mild and efficient protection of diol and carbonyls as cyclic acetals catalysed by iron (III) chloride Comptes Rendus Chimie, Elsevier Masson 2011

A friendly method for the protection of diols and carbonyls catalysed by hexahydrated iron (III) chloride has been developed. This method, which consists of the transformation of diols and carbonyls to cyclic acetals, functions in mild conditions and it is efficient for a wide range of diols

Iyad Karamé Synthese de Nouvelles Bases de Schiff Pour la Catalyse Asymétrique Editions universitaires europeennes EUE 2011

Dans ce travail de thèse, nous avons mis au point une nouvelle méthode de synthèse des bases de Schiff tétraazotées chirales, qui possèdent en positions ortho et para des noyaux aromatiques, des fonctions amines ou sulfonamides. Ensuite ces bases de Schiff ont servi de ligands pour préparer des complexes avec des métaux de transition. Nous avons pu isoler et caractériser un certain nombre de ces complexes notamment avec le cuivre, le cobalt, le nickel et le zinc. Une structure biszwittérionique du ligand (1R,2R)-N,N'-bis(2-triflataaminobenzylidène)-1,2- diaminocyclohexane (H2CyTf) 23 a été mise en évidence par diffraction X et par RMN. Ces bases de Schiff utilisées en hydrogénation asymétrique d'acétophénone en présence des précurseurs de ruthénium, nous ont permis d'obtenir des résultats intéressants.Une conversion complète et un excès énantiomérique de 76% ont été obtenus avec le système Ru(PPh3)3Cl2/(1R,2R)-N,N'-bis(2-p- tosylaminobenzylidène)-1,2-diphényléthylénediamine 29. Nous avons aussi mis au point une nouvelle méthode efficace et régiosélective pour le réarrangement de Meinwald catalysé par le IrCl3.xH2O

Iyad Karamé, Malika Boualleg, Jean‐Michel Camus, Tarun K Maishal, Johan Alauzun, Jean‐Marie Basset, Christophe Copéret, Robert JP Corriu, Erwan Jeanneau, Ahmad Mehdi, Catherine Reyé, Laurent Veyre, Chloé Thieuleux Tailored Ru‐NHC Heterogeneous Catalysts for Alkene Metathesis Chemistry-A European Journal, WILEY‐VCH Verlag 2009

Well-defined, active and reusable Ru-NHC heterogeneous catalysts for metathesis of functionalized olefins were obtained by i) designing a tailored hybrid mesostructured material that contains regularly distributed imidazolium units and ii) the subsequent transformation of such imidazolium moieties into Ru-NHC active sites

Chloe Thieuleux, Christophe Coperet, Laurent Veyre, Robert Corriu, Catherine Reye, Ahmad Mehdi, Jean-Marie Basset, Tarun Maishal, Malika Boualleg, Iyad Karame, Jean-Michel Camus, Johan Alauzun Patent: Hybrid organic-inorganic materials that contain stabilized carbene International Patent WO/2009/092814 International Application No.: PCT/EP2009/050810 2009

The present invention relates to materials and particularly “organometallic-organic-inorganic hybrid materials” that can be used as heterogeneous catalysts for selective catalytic reactions. More precisely this invention relates to organic-inorganic hybrid nanostructured materials comprising a regularly distributed stabilized carbene that binds strongly to a metal so as to form a stable organometallic-organic-inorganic hybrid material having high catalytic performances.

Jean-Marie Basset, Denis Bouchu, Gregory Godard, Iyad Karamé, Emile Kuntz, Frédéric Lefebvre, Nicolas Legagneux, Christine Lucas, Daniel Michelet, Jean Bernard Tommasino Heterolytic Splitting of Allylic Alcohols with Palladium (0)− TPPTS in Water. Stabilities of the Allylphosphonium Salt of TPPTS and of the Ionic Complex [Pd (η3-allyl)(TPPTS) 2]+ Organometallics, American Chemical Society 2008

Allyl alcohol, 2-buten-1-ol, prenol, geraniol, and cinnamyl alcohol react in water with Pd(TPPTS)3 to produce hydrosoluble cationic palladium complexes, allylic phosphonium salts, and hydroxide ions. The stabilities of the allylphosphonium salt of TPPTS and of the ionic complex [Pd(η3-allyl)(TPPTS)2]+ in water were then examined; it was found that temperature and high pH have an adverse effect on their stability

Iyad Karamé, Esen Bellur, Sven Rotzoll, Peter Langer, Christine Fischer, Jens Holz, Armin Börner Highly Enantioselective Hydrogenation of β‐Alkyl and β‐(ω‐Chloroalkyl) Substituted β‐Keto Esters Synthetic communications, Taylor & Francis Group 2007

Highly enantioselective hydrogenation of β‐alkyl and β‐(ω‐chloroalkyl) substituted β‐keto esters was achieved with Ru catalysts based on chiral diphosphines in EtOH at 50°C under 50‐bar initial hydrogen pressure, affording the corresponding β‐hydroxy esters in >98% ee

Peter R Lassen, Laure Guy, Iyad Karame, Thierry Roisnel, Nicolas Vanthuyne, Christian Roussel, Xiaolin Cao, Rosina Lombardi, Jeanne Crassous, Teresa B Freedman, Laurence A Nafie Synthesis and vibrational circular dichroism of enantiopure chiral oxorhenium (V) complexes containing the hydrotris (1-pyrazolyl) borate ligand Inorganic Chemistry, American Chemical Society 2006

New chiral oxorhenium(V) complexes have been synthesized in enantiopure form, and their absolute configurations have been determined by vibrational circular dichroism spectroscopy and by X-ray crystallography.

Iyad Karamé, M Lorraine Tommasino, René Faure, Bernard Fenet, Marc Lemaire Intramolecular Proton Transfer Inducing a Biszwitterion Structure in a N4 Schiff Base Chemistry Letters, Chemical Society of Japan 2004

X-ray and NMR evidences of a sulfonated and tetradentate N4 Schiff base pointed out unusual iminium groups. This produces amide groups and the protons transfer leads to an overall biszwitterion structure

Iyad Karamé, Mohamed Jahjah, Abdelhalim Messaoudi, M Lorraine Tommasino, Marc Lemaire New ruthenium catalysts containing chiral Schiff bases for the asymmetric hydrogenation of acetophenone Tetrahedron: Asymmetry, Elesevier 2004

A series of new chiral N4-Schiff bases, containing amine or sulfonamide functionalities has been synthesized. Coupled with ruthenium catalysts, these Schiff bases induce interesting results in the hydrogenation of acetophenone: complete conversion and 76% ee were obtained with the catalytic system Ru(PPh3)3Cl2/(1R,2R)-N,N′-bis-(2-p-tosylaminobenzylidene)-1,2-diphenylethylenediamine. A very important phosphine co-ligand effect was observed on both activity and enantioselectivity of the catalysts. However, without the co-ligand, we obtained an enantioselectivity for the (R)-enantiomer, whereas with nonchiral co-ligand an enantioselectivity for the (S)-enantiomer was observed

Iyad Karamé, M Lorraine Tommasino, Marc Lemaire N,N- and N,S- ligands for the enantioselective hydrosilylation of acetophenone with iridium catalysts J. Mol. Cat A: chemical,; Elsevier 2003

Enantiomerically pure C2-symmetric diamines and dithioureas as well as a series of monothioureas have been tested as chiral inducers for hydrosilylation of acetophenone with iridium catalysts. Some new N, S-ligands have been synthesized in good yields, one of them bearing four chiral centers. Enantioselectivities with dithioureas are better than the ones observed with analog diamine ligands. Up to 74% ee was reached for acetophenone hydrosilylation with a 10-fold excess of ligand versus iridium precursor

Iyad Karamé, M Lorraine Tommasino, Marc Lemaire Iridium-catalyzed alternative of the Meinwald rearrangement Tetrahedron letters, Pergamon 2003


Iyad Karamé, M. Lorraine Tommasino, René Faure and Marc Lemaire Easy Synthesis of New Chiral Tetradentate N4 Schiff Bases and Their Use as Ligands for Metal Complexes European Journal of Organic Chemistry, WILEY‐VCH Verlag 2003

The chiral N4 Schiff bases (1R,2R)-N,N′-bis(2-p-tosylaminobenzylidene)-1,2-diaminocyclohexane (H2CyTs, 1), (1R,2R)N,N′-bis(2-trifluoromethylsulfonaminobenzylidene)-1,2-diaminocyclohexane (H2CyTf, 2), (1R,2R)-N,N′-bis(2-aminobenzylidene)-1,2-diaminocyclohexane (3) and (1R,2R)-N,N′-bis(2-nitrobenzylidene)-1,2-diaminocyclohexane (4) were synthesized by a new and easy method in high purity and good yields. All the organic compounds were characterized by elemental analysis, mass spectrometry, IR and 1H and 13C NMR spectroscopy. Divalent Co, Cu and Ni complexes 5−8, containing the sulfonamide ligands 1 or 2, have been prepared and characterized. The X-ray crystal structures of complexes [Co(1R,2R)-CyTs] (6) and [Ni(1R,2R)-CyTf] (8) have been solved. These complexes are potential precursors for homogeneous asymmetric catalysis of a variety of reactions.

Supervision 14 Supervised Students
Préparation des bases de Schiff tétraazotés, d'utilses leurs complexesm métalliques comme catalyseurs de la réaction d’addition du CO2 sur les époxydes

Houda Tellawi
Des ligands bases de Schiff tétraazotés N4 déjà décrites dans la thèse d’Iyad Karamé ont été synthétisés dans le but de les utiliser dans la réaction de cycloaddition du CO2 avec les époxydes. Un nouveau ligand dérivé de 1,2-phénylènediamine a été préparé avec succès. Nous avons préparé aussi le méso-hydrobenzoine et l’hydrobenzoine racémique, le 1, 2-spirocyclohexane-4, 5-diphényl-2H-imidazole et 2,3-diphényl-1,4- diazaspiro [4.5]dec-1-ène avec de très bons rendements.

Tetraza-Schiff bases ligands already described in the thesis of Iyad Karamé were synthesized in order to be used in the cycloaddition reaction of CO2 with epoxides. A new Schiff base derived from 1, 2-phenylenediamine was prepared. We succeed to prepare the meso-hydrobenzoin and the hydrobenzoin racémique, the 1, 2-spirocyclohexane-4,5-diphenyl-2H-imidazole and 2,3-diphenyl-1,4-diazaspiro[4.5]dec-1-ene were prepared in good yields. Keywords : catalyst ; Schiff base ; cyclic carbonate ; epoxide ; carbon dioxide

New methods for synthesis of chelating resorcin[4]arene cavitands for complexation of heavy metals

Ahmad Farouk Kassir

A new method of synthesizing a novel resorcin[4]arene (cavitand 5) rigidified by methylene bridges and derived from resorcinol and benzaldehyde was developed. The clean method of synthesis avoids the use of non eco-friendly reagent as CH2BrCl. The latter was replaced by CH2Cl2. The cavitand prepared will be a platform to prepare other functionalized cavitands. Keywords : Resorcin[4]arene; Pb2+; Hg2+; Extraction.

Synthèse des macrocycles chélatants pour la complexation des métaux lourds

Wissam Zahreddine
Rapport du stage de Master 2 Recherche Chimie Organique Moléculaire Année 2012-2013

Des nouveaux cavitands, calix [4] résorcinarènes tétra amine-substitués, ont été synthétisés dans le but de leur évaluation en extraction des métaux lourds. Les trois nouveaux cavitands préparés contiennent des bras chélatants avec des fonctions sulfonamides et amides. Des nouvelles méthodes de synthèse ont été mises au point et permet d’obtenir des bons rendements meilleurs de ceux reportés dans la littérature en ce qui concerne les cavitands déjà connus comme les cavitands tétra-azotures, tétracyané et tétraméthylé. Ces méthodes sont propres et évitent l’utilisation des réactifs et des solvants non écocompatibes comme le CH2BrCl et le DMSO

Evaluation des catalyseurs de Fer en acétalisation sélective du glycérol

Adib Abou Ibrahim
Rapport du stage de Master 2 Recherche Chimie-Physique Matériaux et Catalyse Année 2012-2013

Une nouvelle méthode d’acétalisation du glycérol catalysée par le fer FeCl3.6H2O a été développée. Cette méthode d’acétalisation qui consiste à transformer le glycérol en acétals cycliques dans des conditions douces, sans solvant et en présence d’un catalyseur biocompatible. Cette méthode nous a permit d’obtenir des nouveaux résultats intéressants: une excellente (98%) sélectivité envers des dioxalanes (cycle à 5) est obtenue dans l’acétalisation du glycérol avec des cétones. Pour l’acétalisation avec les aldéhydes nous arrivons à avoir une bonne sélectivité (79%) envers des dioxanes (les acétals cycliques à six chainons)

Méthodologies de synthèse des systèmes chélatants pour la décorporation des métaux lourds

Lina Abou Ibrahim
Rapport du stage de Master 2 Master 2 Professionnel, Instrumentation et Stratégies d’Analyse Année 2011-2012

Une méthode de synthèse alternative de tetrakis (aminomethyl) calix-4-résorcinarène V à partir de tetrakis (azidomethyl) calix-4-résorcinarène IV a été mise au point. Le bromochlorométhane, composé destructeur de l’ozone, a été remplacé par le dichlorométhane dans la réaction de transformation du cavitand octa-hydroxylé I en tetrakis (méthyle) calix-4-résorcinarène II. Les synthèses des cinq cavitands ont été optimisées afin d’obtenir des bons rendements (79-88%)

Synthèse des Systèmes Chélatants Macrocycliques Pour le Traitement d’Effluents Contaminés

Nabil Zein
Master 2 Recherche en Chimie Organique Moléculaire Année 2011-2012

Une nouvelle méthode de synthèse, en six étapes, de calix [4] résorcinarènes tétra aminé V a été mise au point. Cette méthode est plus propre et évite l’utilisation du bromochlorométhane. Toutes les étapes de synthèse ont été réalisées efficacement avec des rendements meilleurs à ceux reportés dans la littérature. Tous les produits ont été caractérisés par RMN 1H et IR

Protection de Triol et Polyol Catalysée par le Fer: Valorisation de glycérol et de sorbitol

Khaled Al Adraa
Master 2 Professionnel INSTRUMENTATION ET STRATEGIES D’ANALYSE Année 2010-2011

Une nouvelle étude de protection des triols et des polyols catalysé par deux catalyseurs à base de Fer FeCl3.6H2O et un système catalytique FeCl3.6H2O avec ligand). Ce protection qui consiste à transformer les oles en acétals ou cétals cycliques dans des conditions douces et avec une très faible quantité de catalyseurs (10 moles %), nous a permit d’explorer des nouveaux résultats inattendues. Ces observations qui peuvent aboutir a des découverte importantes feront objet d’une étude approfondie dans la suite.

Préparation d’un catalyseur à base de tungstène pour la réaction de la métathèse

Chouaa Abou Faour
Master 2 Recherche Mention: Chimie-Physique, Matériaux et Catalyse Année 2009-2010

Le travail de ce mémoire fait une partie d’un projet qui a pour but la synthèse d’un nouveau catalyseur chiral supporté à base de tungstène pour la réaction.de « ring-closing metathesis » asymétrique. Un dérivé de BINOL porteur de groupements phényles en positions 3 et 3’ a été préparé en quatre étapes à partir de BINOL. La synthèse de ce ligand consiste à réaliser un couplage aromatique-aromatique de type suzuki en utilisant le BINOL dibromé. Ce dernier dérivé de BINOL est obtenu suite à deux réactions d’ortho métallation et de bromination subites sur le BINOL protégé

Synthesis of chelating systems for the elimination of hard metals and decontamination of effluent discharge.

Manal Sharaf
M2 Research Project Année 2009-2010

The synthesis of a resorcinaric ligand bearing four N-methyl-sulfonylcarboxamide arms is reported in six steps, starting from the monomer 2-metylresorcinol. All synthesis steps were carried out efficiently and the yields obtained are in the most cases better than those already reported in the literature. The prepared cavitand will be evaluated in the complexation of lead which is highly toxic metal

Fonctionnalisation des polyosides par télomérisation avec l’isoprène et le butadiène

Wissam Zahreddine
PhD thesis, 2013-2016

Préparation des systèmes chélatants pour l'extraction sélective des ions métalliques, Lanthanides et actinides

Moheddine Wehbie
PhD Thesis 2012-2016

Synthèse des ligands azotés énantiopurs et évaluation de leurs complexes métalliques en catalyse asymétrique

Bilal Asaad
PhD Thesis 2013-2016

Title of Thesis: Photothermal Solar Receptors Electrophoretic Deposition of Nanoparticles of Optical Selective Properties

Sanaa Shehayeb
PhD thesis 2014-2017

Synthèse et réactivité des carbonates : Application à la synthèse de polyuréthanes sans isocyanate

Nadim EID
Sustainable and Green Catalysis using CO2

A l’aune d’un durcissement de la règlementation et avec la volonté de protéger la population, le remplacement des réactifs toxiques devient tous les jours plus urgent. En particulier, envisager le remplacement des isocyanates devient une priorité car ils sont utilisés à très grande échelle, notamment pour la synthèse de polyurethanes (PUs). Les Non-Isocyanates Polyurethanes (NIPUs) préparés par (poly)aminolyse de polycarbonates constituent une alternative prometteuse car non seulement leur structure et leurs propriétés se rapprochent de celles des PUs, mais de plus, leur synthèse ne requiert par l’utilisation de réactifs très toxiques. Cependant, la faible réactivité des carbonates vis-à-vis des amines nécessite le développement de systèmes catalytiques performants permettant d’atteindre les masses voulues à basse température, tout en ne colorant pas le polymère en fin de réaction. Pour l’heure, les systèmes proposés dans la littérature ne permettent pas encore d’atteindre une réactivité suffisante pour permettre l’obtention de NIPUs de hauts poids moléculaires. Dans ce cadre, l’objectif de cette thèse sera de développer un système catalytique efficace permettant l’aminolyse de cyclocarbonates à 5 ou 6 chainons dans des conditions douces avec différents types d’amines (primaires, primaires encombrées, aromatiques…). Le choix du système catalytique devra respecter le cahier des charges indiqué ci-dessus tout en présentant une faible toxicité. Si les organocatalyseurs constitueront une cible de choix, une catalyse organométal lique pourra également être envisagée. Un second aspect du travail de thèse aura trait au développement d’un système catalytique permettant de contracter le cyclocarbonate afin de générer un époxyde in situ. Cette réaction décrite en catalyse hétérogène et/ou dans des conditions drastiques devra pouvoir être réalisées en catalyse homogène, dans des conditions douces. L’époxyde pourra être ensuite réagir plus en avant avec l’amine présente dans le milieu et permettre l’obtention de polymères de plus hautes masses.


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