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Cellular and molecular Aspects of development Description

Key Elements

Code

BIOA 440

Formation

M1 Cellular and Molecular Biology - Section 2

Semester

1

Credits

4

Number of Teaching Hours

36

Number of Tutoring Sessions

0

Number of Laboratory Sessions

0

This course is optional

Content

Objective

The aim of this course is to provide the student with a thorough cellular and molecular mechanisms of development, and to supply him with an introduction to pathologic development as well as to some modern techniques. To achieve the goal, the course discusses the following aspects. After recalling basic concepts of genetics, a first part explores the embryonic development of Drosophila, the determination of anteroposterior axis and dorso-ventral axis and the importance of homeotic genes. In a second part, we will address the molecular and cellular mechanisms of folliculogenesis and during the third part we will focus specifically on sexual differentiation including examples of pathology of development and notions of teratology. In TD sessions, students will become familiar with the analysis of scientific papers

Content

Introduction to genetic and molecular analysis Presentation of the Drosophila model Establishment of polarity during embryonic development Homeotic genes Regulation of the genome and cell differentiation folliculogenesis Gonadrotopines Hypothalamic control of reproduction Ovarian stimulation and PMA Sex determination Development abnormalities and teratogenicity References • Bases cellulaires et moléculaires du développement, Christophe Chanoine, 2007 • Cell lineage and fate determination, Sally A Moody, 2000 • La reproduction, Gonades, gamètes et fécondation, Nathan, 1997