The aim of this course is to provide the student with a thorough cellular and molecular mechanisms of development, and to supply him with an introduction to pathologic development as well as to some modern techniques.
To achieve the goal, the course discusses the following aspects. After recalling basic concepts of genetics, a first part explores the embryonic development of Drosophila, the determination of anteroposterior axis and dorso-ventral axis and the importance of homeotic genes.
In a second part, we will address the molecular and cellular mechanisms of folliculogenesis and during the third part we will focus specifically on sexual differentiation including examples of pathology of development and notions of teratology.
In TD sessions, students will become familiar with the analysis of scientific papers
Introduction to genetic and molecular analysis
Presentation of the Drosophila model
Establishment of polarity during embryonic development
Regulation of the genome and cell differentiation
Hypothalamic control of reproduction
Ovarian stimulation and PMA
Development abnormalities and teratogenicity
• Bases cellulaires et moléculaires du développement, Christophe Chanoine, 2007
• Cell lineage and fate determination, Sally A Moody, 2000
• La reproduction, Gonades, gamètes et fécondation, Nathan, 1997