This course focuses on major concepts in microbiology and infectious diseases in a pathological framework and within the context of clinical cases. Immune defense against infectious agents and pathogen evasion from the immune system are detailed. In addition, interactions of plants and pathogens and immunity in invertebrates are reviewed. Aspects of host-pathogen interactions are covered at the cellular and molecular level, drawing heavily on the disciplines of genetics, biochemistry, molecular biology, and cell biology
1. Establishment of infectious diseases: mechanisms of host detection, colonization/ multiplication, virulence, and the maintenance of infection.
2. Genetic approaches to study bacterial pathogenesis
3. Damage by microbial toxins
4. Immune defense (initial, innate and adaptive) against infectious agents: viruses, bacteria (extracellular and intracellular), fungi and parasites
5. Pathogen evasion of immune responses by different strategies
6. Tissue damage resulting from the immune response to different pathogens
7. Biological basis for antibacterial actions, antimicrobial therapy, vaccines and antisera for the prevention and treatment of infectious diseases
8. Plant-microorganism interactions (mutualistic and antagonistic interactions, plant perception of microbial signals, associated local and systemic defense mechanisms)
9. Immunity in invertebrates (insects-microbes interactions)
TS: Selected examples of current research on host-pathogen interactions mainly based on microbial evasion from the immune system and mechanisms of pathogenicity.